Bioactive compounds, Antioxidant and Antimicrobial Attributes of Cordia Sinensis Lam
DOI:
https://doi.org/10.38211/joarps.2024.05.239Keywords:
Antimicrobial activity, Antioxidants, Bioactive Compounds, Cordia sinensis, Medicinal PlantAbstract
The aim of this study is to discover the efficacy of various parts of Cordia sinensis plant against some particular pathogens that are recognized to cause diseases and to check antioxidant and bioactive compounds from different parts of plant C. sinensis. Plant extracts were examined by quantification of phytochemical compounds and antimicrobial activity. Phytochemicals and several secondary metabolites were quantified and also qualitatively analyzed in C. sinensis extracts such as phenolic compounds, flavonoids, alkaloids, tannins, steroids, glycosides, and saponins. Similarly, biochemical primary metabolites like protein, total sugar, and reducing sugar were also estimated in different parts of C. sinensis and these results correlated with antimicrobial activity. This study reveals that acetone extracts of stems, leaves, and roots of the C. sinensis showed excellent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumonia and also against fungal species Aspergillus niger, Candida albicans, and Penicillium notatum.
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Abaka, K., Gali, A., Haruna, A., & Ardo, P. (2020). Phytochemicals screening and antifungal activity of Balanites aegyptiaca Seed and Callus Extract against Candida albicans. Asian Plant Res J, 4(4), 9-16. DOI: https://doi.org/10.9734/aprj/2020/v4i430091
Agbafor, K. N., Engwa, G., & Obiudu, I. (2015). Analysis of chemical composition of leaves and roots of Ageratum conyzoides. International Journal of Current Research and Academic Review, 3(11), 60-65.
Ajayi, I., Ajibade, O., & Oderinde, R. (2011). Preliminary phytochemical analysis of some plant seeds. Res J Chem Sci, 1(3), 58-62.
Al-Farsi, M. A., & Lee, C. Y. (2008). Optimization of phenolics and dietary fibre extraction from date seeds. Food Chemistry, 108(3), 977-985. DOI: https://doi.org/10.1016/j.foodchem.2007.12.009
Arabshahi-D, S., Devi, D. V., & Urooj, A. (2007). Evaluation of antioxidant activity of some plant extracts and their heat, pH and storage stability. Food Chemistry, 100(3), 1100-1105. DOI: https://doi.org/10.1016/j.foodchem.2005.11.014
Bailly, C., & Vergoten, G. (2020). Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome? Pharmacology & therapeutics, 214, 107618. DOI: https://doi.org/10.1016/j.pharmthera.2020.107618
Batubara, R., HANUM, T. I., HANDIKA, A., & AFFANDI, O. (2020). The screening of phytochemical and antioxidant activity of agarwood leaves (Aquilaria malaccensis) from two sites in North Sumatra, Indonesia. Biodiversitas Journal of Biological Diversity, 21(4). DOI: https://doi.org/10.13057/biodiv/d210440
BATUBARA, R., SURJANTO, S., SIHOMBING, T. M., & GINTING, H. (2016). The safety of tea agarwood (Aquilaria malaccensis) from tree induction through test of toxicity subchronic oral 90 days. Asian Journal of Natural Product Biochemistry, 14(2), 69-76. DOI: https://doi.org/10.13057/biofar/f140205
Benedec, D., Vlase, L., Oniga, I., Mot, A. C., Damian, G., Hanganu, D., . . . Silaghi-Dumitrescu, R. (2013). Polyphenolic composition, antioxidant and antibacterial activities for two Romanian subspecies of Achillea distans Waldst. et Kit. ex Willd. Molecules, 18(8), 8725-8739. DOI: https://doi.org/10.3390/molecules18088725
BENMAGHNIA, S., MEDDAH, B., TIR-TOUIL, A., & HERNÁNDEZ, J. A. G. (2021). Phytochemical analysis, antioxidant and antimicrobial activities of three samples of dried figs (ficus carica l.) from the region of mascara. Journal of Microbiology, Biotechnology and Food Sciences, 2021, 208-215. DOI: https://doi.org/10.15414/jmbfs.2019.9.2.208-215
Böhm, M., Kario, K., Kandzari, D. E., Mahfoud, F., Weber, M. A., Schmieder, R. E., . . . Choi, J. W. (2020). Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. The Lancet, 395(10234), 1444-1451. DOI: https://doi.org/10.1016/S0140-6736(20)30554-7
Bruck de Souza, L., Leitão Gindri, A., de Andrade Fortes, T., Felli Kubiça, T., Enderle, J., Roehrs, R., . . . Gasparotto Denardin, E. L. (2020). Phytochemical analysis, antioxidant activity, antimicrobial activity, and cytotoxicity of chaptalia nutans leaves. Advances in Pharmacological and Pharmaceutical Sciences, 2020. DOI: https://doi.org/10.1155/2020/3260745
Chao, C.-H., Cheng, J.-C., Shen, D.-Y., Huang, H.-C., Wu, Y.-C., & Wu, T.-S. (2016). Terpenoids from Flueggea virosa and their anti-hepatitis C virus activity. Phytochemistry, 128, 60-70. DOI: https://doi.org/10.1016/j.phytochem.2016.04.003
Classics Lowry, O., Rosebrough, N., Farr, A., & Randall, R. (1951). Protein measurement with the Folin phenol reagent. J biol Chem, 193(1), 265-275. DOI: https://doi.org/10.1016/S0021-9258(19)52451-6
Desmiaty, Y., Ratih, H., Dewi, M. A., & Agustín, R. (2008). Penentuan jumlah tanin total pada daun jati belanda (Guazuma ulmifolia Lamk) dan daun sambang darah (Excoecaria bicolor Hassk.) secara kolorimetri dengan pereaksi biru prusia. Ortocarpus, 8, 106-109.
Dey, P., Kundu, A., Chakraborty, H. J., Kar, B., Choi, W. S., Lee, B. M., . . . Kim, H. S. (2019). Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives. International journal of cancer, 145(7), 1731-1744. DOI: https://doi.org/10.1002/ijc.31965
Djeridane, A., Yousfi, M., Nadjemi, B., Boutassouna, D., Stocker, P., & Vidal, N. J. (2006). Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. 97(4), 654-660. DOI: https://doi.org/10.1016/j.foodchem.2005.04.028
Duru, I. A. (2020). Comparative Phytochemical Analysis of Brown, Green and Red Propolis from Umudike, Abia State Nigeria.
Eltayeib, A. A., & Ishag, W. (2015). Phytochemical screening, antimicrobial, antioxidant and cytotoxicity activities of bark’s crude extracts of Cordia sinensis. Adv. Med. Plant Res, 2, 39-45.
Farnsworth, N. R. (1966). Biological and phytochemical screening of plants. Journal of pharmaceutical sciences, 55(3), 225-276. DOI: https://doi.org/10.1002/jps.2600550302
Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., . . . Malaník, M. (2019). Berberine in cardiovascular and metabolic diseases: from mechanisms to therapeutics. Theranostics, 9(7), 1923. DOI: https://doi.org/10.7150/thno.30787
Graziela Moraes, G., Mazziero, M., Lovatto, M., Dornelles, R. C., Nogueira-Librelotto, D. R., Reuter, C. P., . . . Manfron, M. P. (2021). Preliminary phytochemical analysis and evaluation of the antioxidant and anti-proliferative effects of Plinia peruviana leaves: an in vitro approach. Natural product research, 35(5), 836-844. DOI: https://doi.org/10.1080/14786419.2019.1602827
Gul, R., Jan, S. U., Faridullah, S., Sherani, S., & Jahan, N. (2017). Preliminary phytochemical screening, quantitative analysis of alkaloids, and antioxidant activity of crude plant extracts from Ephedra intermedia indigenous to Balochistan. The Scientific World Journal, 2017. DOI: https://doi.org/10.1155/2017/5873648
Gumgumjee, N., & Hajar, A. (2015). Antimicrobial efficacy of Acacia saligna (Labill.) HL Wendl. and Cordia sinensis Lam. leaves extracts against some pathogenic microorganisms. Int. J. Microbiol. Immunol. Res, 3(4), 51-57.
Hill, R. A., & Connolly, J. D. (2020). Triterpenoids. Natural Product Reports, 37(7), 962-998. DOI: https://doi.org/10.1039/C9NP00067D
Hossain, M. A., AL-Raqmi, K. A. S., Al-Mijizy, Z. H., Weli, A. M., & Al-Riyami, Q. (2013). Study of total phenol, flavonoids contents and phytochemical screening of various leaves crude extracts of locally grown Thymus vulgaris. Asian Pacific Journal of Tropical Biomedicine, 3(9), 705-710. DOI: https://doi.org/10.1016/S2221-1691(13)60142-2
Hussain, G., Rasul, A., Anwar, H., Aziz, N., Razzaq, A., Wei, W., . . . Li, X. (2018). Role of plant derived alkaloids and their mechanism in neurodegenerative disorders. International journal of biological sciences, 14(3), 341. DOI: https://doi.org/10.7150/ijbs.23247
Imran, I., Khalid, H. L., & Asghar, A. (2011). Anti-microbial efficacy and biochemical analysis from different parts of Acacia nilotica L. and Ricinus communis L. extracts. 5(27), 6299-6308. DOI: https://doi.org/10.5897/JMPR11.533
Jaberian, H., Piri, K., & Nazari, J. (2013). Phytochemical composition and in vitro antimicrobial and antioxidant activities of some medicinal plants. Food Chemistry, 136(1), 237-244. DOI: https://doi.org/10.1016/j.foodchem.2012.07.084
Jeong, M.-R., Kim, H.-Y., & Cha, J.-D. (2009). Antimicrobial activity of methanol extract from Ficus carica leaves against oral bacteria. Journal of Bacteriology and Virology, 39(2), 97-102. DOI: https://doi.org/10.4167/jbv.2009.39.2.97
Johari, M. A., & Khong, H. Y. (2019). Total phenolic content and antioxidant and antibacterial activities of Pereskia bleo. Advances in pharmacological sciences, 2019. DOI: https://doi.org/10.1155/2019/7428593
Jouda, M. M., Bashiti, T. A., Masad, A. A., & Dardona, Z. W. (2015). Synergistic effect of Ficus sycomorus (Moraceae) leaf and stem-bark extracts against Some Selected Pathogens. International Journal of Scientific and Research Publications, 5(12).
Khan, J., Majid, A., Nazir, N., Nisar, M., Khan Khalil, A. A., Zahoor, M., . . . Shah, A. B. (2021). HPLC Characterization of Phytochemicals and Antioxidant Potential of Alnus nitida (Spach) Endl. Horticulturae, 7(8), 232. DOI: https://doi.org/10.3390/horticulturae7080232
Khan, K., Rasheed, M., Nadir, M., Firdous, S., & Faizi, S. (2021). Phytochemical and pharmacological profile with biogenetic correlation of bioactive phytoconstituents from the stems of Cordia sinensis Lam. Natural product research, 35(3), 525-528. DOI: https://doi.org/10.1080/14786419.2019.1637872
Konan, Y., Witabouna, K. M., Bassirou, B., & Kagoyire, K. (2014). Antioxidant activity and total phenolic content of nine plants from Côte d'Ivoire (West Africa). Journal of Applied Pharmaceutical Science, 4(8), 36.
Kumar, M., Puri, S., Pundir, A., Bangar, S. P., Changan, S., Choudhary, P., . . . Damale, R. D. (2021). Evaluation of nutritional, phytochemical, and mineral composition of selected medicinal plants for therapeutic uses from cold desert of Western Himalaya. Plants, 10(7), 1429. DOI: https://doi.org/10.3390/plants10071429
Lachance, P. A., Nakat, Z., & Jeong, W.-S. (2001). Antioxidants: an integrative approach. Nutrition (Burbank, Los Angeles County, Calif.), 17(10), 835-838. DOI: https://doi.org/10.1016/S0899-9007(01)00636-0
Majnooni, M. B., Fakhri, S., Bahrami, G., Naseri, M., Farzaei, M. H., & Echeverría, J. (2021). Alkaloids as potential phytochemicals against SARS-CoV-2: approaches to the associated pivotal mechanisms. Evidence-based Complementary and Alternative Medicine, 2021. DOI: https://doi.org/10.1155/2021/6632623
Makris, D. P., Boskou, G., & Andrikopoulos, N. K. (2007). Polyphenolic content and in vitro antioxidant characteristics of wine industry and other agri-food solid waste extracts. Journal of Food Composition and Analysis, 20(2), 125-132. DOI: https://doi.org/10.1016/j.jfca.2006.04.010
Marini, G., Graikou, K., Zengin, G., Karikas, G. A., Gupta, M. P., & Chinou, I. (2018). Phytochemical analysis and biological evaluation of three selected Cordia species from Panama. Industrial Crops and Products, 120, 84-89. DOI: https://doi.org/10.1016/j.indcrop.2018.04.037
Mega, I., & Swastini, D. (2010). Phytochemical screening and free antiradical activity of gaharu leaf methanol extract (Gyrinops versteegii). Chemistry Journal, J Kimia, 4(2), 187-192.
Miller, G. L. (1959). Use of dinitrosalicylic acid reagent for determination of reducing sugar. Analytical chemistry, 31(3), 426-428. DOI: https://doi.org/10.1021/ac60147a030
Miron, V. V., Bottari, N. B., Assmann, C. E., Stefanello, N., da Costa, P., Pelinson, L. P., . . . da Cruz, I. B. M. (2019). Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide‐induced sepsis in rats. Journal of Cellular Biochemistry, 120(3), 3232-3242. DOI: https://doi.org/10.1002/jcb.27590
Montgomery, R. (1961). Further studies of the phenolsulfuric acid reagent for carbohydrates. Biochimica et Biophysica Acta, 48, 591-593. DOI: https://doi.org/10.1016/0006-3002(61)90059-2
Muhongo, M. N., Kangogo, M., & Bii, C. (2021). Qualitative and quantitative phytochemical profiling of crude fractions of Pechuel-Loeschea leubnitziae leaves. Journal of medicinal plants Research, 15(2), 64-72. DOI: https://doi.org/10.5897/JMPR2020.7073
Naikoo, M. I., Dar, M. I., Raghib, F., Jaleel, H., Ahmad, B., Raina, A., . . . Naushin, F. (2019). Role and regulation of plants phenolics in abiotic stress tolerance: An overview. Plant signaling molecules, 157-168. DOI: https://doi.org/10.1016/B978-0-12-816451-8.00009-5
Owolabi, O. O., James, D. B., Sani, I., Andongma, B. T., Fasanya, O. O., & Kure, B. (2018). Phytochemical analysis, antioxidant and anti-inflammatory potential of Feretia apodanthera root bark extracts. BMC Complementary and Alternative Medicine, 18(1), 1-9. DOI: https://doi.org/10.1186/s12906-017-2070-z
Oza, M. J., & Kulkarni, Y. A. (2017). Traditional uses, phytochemistry and pharmacology of the medicinal species of the genus Cordia (Boraginaceae). Journal of Pharmacy and Pharmacology, 69(7), 755-789. DOI: https://doi.org/10.1111/jphp.12715
Phull, A.-R., Ali, A., Ali, A., Abbasi, S., Zia, M., Khaskheli, M. H., & Kamal, M. A. (2020). Synthesis of Silver Nanoparticles using Euphorbia wallichii Extract and Assessment of their Bio-functionalities. Medicinal Chemistry, 16(4), 495-506. DOI: https://doi.org/10.2174/1573406415666191111143213
Prabu, K., Rajasekaran, A., Bharathi, D., & Ramalakshmi, S. (2019). Anti-oxidant activity, phytochemical screening and HPLC profile of rare endemic Cordia diffusa. Journal of King Saud University-Science, 31(4), 724-727. DOI: https://doi.org/10.1016/j.jksus.2018.04.025
Proestos, C., Lytoudi, K., Mavromelanidou, O. K., Zoumpoulakis, P., & Sinanoglou, V. J. (2013). Antioxidant capacity of selected plant extracts and their essential oils. Antioxidants, 2(1), 11-22. DOI: https://doi.org/10.3390/antiox2010011
Rahman, M. A., & Akhtar, J. (2016). A new linoleiyl arabinopyranoside from the bark of Bauhinia racemosa Lam and a new flavonoidal glycoside from the leaves of Cordia dichotoma Linn. Natural product research, 30(20), 2265-2273. DOI: https://doi.org/10.1080/14786419.2016.1163694
Rahu, M. I., Naqvi, S. H. A., Memon, N. H., Idrees, M., Kandhro, F., Pathan, N. L., . . . Bhutto, M. A. (2021). Determination of antimicrobial and phytochemical compounds of Jatropha curcas plant. Saudi journal of biological sciences, 28(5), 2867-2876. DOI: https://doi.org/10.1016/j.sjbs.2021.02.019
Rao, B. G., Rao, E. S., & Rao, T. M. (2012). Quantification of phytochemical constituents and in-vitro antioxidant activity of Mesua ferrea leaves. Asian Pacific Journal of Tropical Biomedicine, 2(2), S539-S542. DOI: https://doi.org/10.1016/S2221-1691(12)60269-X
Rashid, K. I., Mahdi, N. M., Alwan, M. A., & Khalid, L. B. (2014). Antimicrobial activity of fig (Ficus carica Linn.) leaf extract as compared with latex extract against selected bacteria and fungi. Journal of Babylon University/Pure and Applied Sciences, 5(22), 1620-1626.
Roghini, R., & Vijayalakshmi, K. (2018). Phytochemical screening, quantitative analysis of flavonoids and minerals in ethanolic extract of Citrus paradisi. Int J Pharm Sci & Res, 9(11), 4859-4864.
Rosales, P. F., Bordin, G. S., Gower, A. E., & Moura, S. (2020). Indole alkaloids: 2012 until now, highlighting the new chemical structures and biological activities. Fitoterapia, 143, 104558. DOI: https://doi.org/10.1016/j.fitote.2020.104558
Ruberto, G., Renda, A., Daquino, C., Amico, V., Spatafora, C., Tringali, C., & De Tommasi, N. (2007). Polyphenol constituents and antioxidant activity of grape pomace extracts from five Sicilian red grape cultivars. Food Chemistry, 100(1), 203-210. DOI: https://doi.org/10.1016/j.foodchem.2005.09.041
Sankhalkar, S., & Vernekar, V. (2016). Quantitative and Qualitative analysis of Phenolic and Flavonoid content in Moringa oleifera Lam and Ocimum tenuiflorum L. Pharmacognosy research, 8(1), 16. DOI: https://doi.org/10.4103/0974-8490.171095
Senguttuvan, J., Paulsamy, S., & Karthika, K. (2014). Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L. for in vitro antioxidant activities. Asian Pacific Journal of Tropical Biomedicine, 4, S359-S367. DOI: https://doi.org/10.12980/APJTB.4.2014C1030
Sharma, N., Dhekne, H. S., & Senapati, S. (2019). Immunomodulatory Potential of Phytochemicals: Recent Updates Phytochemistry: An in-silico and in-vitro Update (pp. 133-160): Springer. DOI: https://doi.org/10.1007/978-981-13-6920-9_8
Surjanto, B. R., Ginting, H., & Silaban, S. (2014). Phytochemical screening of gaharu leaf extract and it potential test as antioxidant tea. Paper presented at the Seminar Nasional MAPEKI XVII, Universitas Sumatera Utara, Medan.
Verdcourt, B. (1991). Flora of Tropical East Africa-Boraginaceae (1991): CRC Press. DOI: https://doi.org/10.1201/9780203755860
Vishnu, R., Nisha, R., Jamuna, S., & Paulsamy, S. (2013). Quantification of total phenolics and flavonoids and evaluation of in vitro antioxidant properties of methanolic leaf extract of Tarenna asiatica-an endemic medicinal plant species of Maruthamali hills, Western Ghats, Tami Nadu. J Res Plant Sci, 2(2), 196-204.
Yasoubi, P., Barzegar, M., SAHARI, M. A., & Azizi, M. (2007). Total phenolic contents and antioxidant activity of pomegranate (Punica granatum L.) peel extracts.
Yildirim, I., & Kutlu, T. (2015). Anticancer agents: saponin and tannin.
Yu, L., Haley, S., Perret, J., Harris, M., Wilson, J., & Qian, M. (2002). Free radical scavenging properties of wheat extracts. Journal of agricultural and food chemistry, 50(6), 1619-1624. DOI: https://doi.org/10.1021/jf010964p
Zakaria, Z., Aziz, R., Lachimanan, Y. L., Sreenivasan, S., & Rathinam, X. (2008). Antioxidant activity of Coleus blumei, Orthosiphon stamineus, Ocimum basilicum and Mentha arvensis from Lamiaceae family. Int J Nat Eng Sci, 2(1), 93-95.
Živković, J., Ćebović, T., & Maksimović, Z. (2012). In vivo and in vitro antioxidant effects of three Veronica species. Open Life Sciences, 7(3), 559-568. DOI: https://doi.org/10.2478/s11535-012-0041-4
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Copyright (c) 2024 Asghar Ali Shaikh, Syed Habib Ahmed Naqvi ; Komal Siddiqui; Farzana Korejo; Zameer Ali Palh, Abdul Sami Dahri, Muhammad Rafiq, Shayan Ali
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